Loading...
Please wait, while we are loading the content...
Genomic approaches to lung cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Meyerson, Matthew L. |
| Copyright Year | 2006 |
| Abstract | The last decade has seen remarkable success in clinical targeting of activated oncogenes in cancer. We have applied gene expression profiling, high-density single-nucleotide polymorphism arrays, and systematic resequencing of genes to identify novel oncogenes and signaling pathways in lung cancer that might represent therapeutic targets. Systematic resequencing of tyrosine kinase genes has led to the discovery of somatic mutations in the epidermal growth factor receptor (EGFR) gene in lung adenocarcinomas. These mutations range in frequency from 10% in Caucasian to 40% in East Asian patients. Lung cancer-derived EGFR mutations are oncogenic and are tightly associated with clinical response to the EGFR kinase inhibitors erlotinib and gefitinib. Furthermore, gene expression profiling has been shown to classify patients according to their clinical outcome, indicating that the application of this technique may help in guiding patient selection for therapy in the future. Finally, genome-wide analyses of copy number gains and losses were successfully applied to detect gene amplifications and deletions. Taken together, the application of genomics technologies has led to important discoveries with clinical implications in lung cancer that might help to improve clinical care for patients suffering from this highly fatal tumor. |
| Starting Page | 4384s |
| Ending Page | 4391s |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://clincancerres.aacrjournals.org/content/clincanres/12/14/4384s.full.pdf |
| PubMed reference number | 16857815v1 |
| Volume Number | 12 |
| Issue Number | 14 |
| Part | 2 |
| Journal | Clinical cancer research : an official journal of the American Association for Cancer Research |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenocarcinoma Carcinoma of lung Copy Number DNA Resequencing Diploid Cell EGFR gene Gene Expression Profiling Growth Factor Receptors Mutation Neoplasms Non-Small Cell Lung Carcinoma Nucleotides Oncogenes Patients Protein Tyrosine Kinase Structure of parenchyma of lung cellular targeting erlotinib gefitinib |
| Content Type | Text |
| Resource Type | Article |
