NDLI: Role of NKT cells in the digestive system. I. Invariant NKT cells and liver diseases: is there strength in numbers?

Content Provider	Semantic Scholar
Author	Ajuebor, Maureen N.
Copyright Year	2007
Abstract	Information regarding the functional role of the innate immune T cell, invariant natural killer T (iNKT) cells, in the pathophysiology of liver diseases continues to emerge. Results from animal studies suggest that iNKT cells can have divergent roles by specifically promoting the development of proinflammatory or anti-inflammatory responses in liver diseases. In this themes article, I discuss the critical evidence from animal models that demonstrate a vital role for iNKT cells in the pathophysiology of liver diseases with emphasis on viral, autoimmune, and toxin-induced liver diseases. Furthermore, I discuss the controversial issues (including iNKT cell apoptosis) that typify some of these studies. Finally, I highlight areas that require additional investigation.
File Format	PDF HTM / HTML
DOI	10.1152/ajpgi.00298.2007
PubMed reference number	17627969
Journal	Medline
Volume Number	293
Issue Number	4
Alternate Webpage(s)	http://ajpgi.physiology.org/content/ajpgi/293/4/g651.full.pdf
Alternate Webpage(s)	https://doi.org/10.1152/ajpgi.00298.2007
Journal	American journal of physiology. Gastrointestinal and liver physiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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