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Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Standish, Beau A. Yang, Victor X. D. Munce, Nigel R. Song, Louis-Michel Wong Kee Gardiner, Geoffrey W. Lin, Annie Mao, Youxin Vitkin, Alex Marcon, Norman Wilson, Brian C. |
| Copyright Year | 2007 |
| Abstract | BACKGROUND Doppler optical coherence tomography (DOCT) is an imaging modality that allows assessment of the microvascular response during photodynamic therapy (PDT) and may be a powerful tool for treatment monitoring/optimization in conditions such as Barrett's esophagus (BE). OBJECTIVE To assess the technical feasibility of catheter-based intraluminal DOCT for monitoring the microvascular response during endoluminal PDT in an animal model of BE. DESIGN Thirteen female Sprague-Dawley rats underwent esophagojejunostomy to induce enteroesophageal reflux for 35 to 42 weeks and the formation of Barrett's mucosa. Of these, 9 received PDT by using the photosensitizer Photofrin (12.5 mg/kg intravenous), followed by 635-nm intraluminal light irradiation 24 hours after drug administration. The remaining 4 surgical rats underwent light irradiation without Photofrin (controls). Another group of 5 normal rats, without esophagojejunostomy, also received PDT. DOCT imaging of the esophagus by using a catheter-based probe (1.3-mm diameter) was performed before, during, and after light irradiation in all rats. RESULTS Distinct microstructural differences between normal squamous esophagus, BE, and the transition zone between the 2 tissues were observed on DOCT images. Similar submucosal microcirculatory effects (47%-73% vascular shutdown) were observed during PDT of normal esophagus and surgically induced BE. Controls displayed no significant microvascular changes. CONCLUSIONS No apparent difference was observed in the PDT-induced vascular response between normal rat esophagus and the BE rat model. Real-time monitoring of PDT-induced vascular changes by DOCT may be beneficial in optimizing PDT dosimetry in patients undergoing this therapy for BE and other conditions. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.gie.2007.02.040 |
| PubMed reference number | 17643708 |
| Journal | Medline |
| Volume Number | 66 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://wwwlabs.uhnresearch.ca/biophotonics/staff_papers/vitkin/2007/2007-GastrointestinalEndoscopy-Standish.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.gie.2007.02.040 |
| Journal | Gastrointestinal endoscopy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
