NDLI: Frustrated Lewis pairs: metal-free hydrogen activation and more.

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Frustrated Lewis pairs: metal-free hydrogen activation and more.

Content Provider	Semantic Scholar
Author	Stephan, Douglas W. Erker, Gerhard
Copyright Year	2010
Abstract	Sterically encumbered Lewis acid and Lewis base combinations do not undergo the ubiquitous neutralization reaction to form "classical" Lewis acid/Lewis base adducts. Rather, both the unquenched Lewis acidity and basicity of such sterically "frustrated Lewis pairs (FLPs)" is available to carry out unusual reactions. Typical examples of frustrated Lewis pairs are inter- or intramolecular combinations of bulky phosphines or amines with strongly electrophilic RB(C(6)F(5))(2) components. Many examples of such frustrated Lewis pairs are able to cleave dihydrogen heterolytically. The resulting H(+)/H(-) pairs (stabilized for example, in the form of the respective phosphonium cation/hydridoborate anion salts) serve as active metal-free catalysts for the hydrogenation of, for example, bulky imines, enamines, or enol ethers. Frustrated Lewis pairs also react with alkenes, aldehydes, and a variety of other small molecules, including carbon dioxide, in cooperative three-component reactions, offering new strategies for synthetic chemistry.
Starting Page	46
Ending Page	76
Page Count	31
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.chemistry.bristol.ac.uk/sillymolecules/FLPs.pdf
PubMed reference number	20025001v1
Alternate Webpage(s)	https://doi.org/10.1002/anie.200903708
DOI	10.1002/anie.200903708
Journal	Angewandte Chemie
Volume Number	49
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	3-oxoadipate enol-lactonase activity Aldehydes Alkenes Amines Anions Carbon Dioxide Cations Chemical acidity/alkalinity DU-PAN-2 Ethers Frustration Hydrogenation Imines Lewis Bases Neutralization (Chemistry) Phosphines Salts Small Molecule Solute Carrier Organic Anion Transporter Family Member 1b1 Synthesis Chemistry Thioctic Acid adduct enol
Content Type	Text
Resource Type	Article

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