NDLI: Insuffisance surrenalenne d’origine auto-immune en milieu tropical : mythe ou réalité

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Insuffisance surrenalenne d’origine auto-immune en milieu tropical : mythe ou réalité

Content Provider	Semantic Scholar
Author	Djiba, Boundia Faye, A. Ndour, Michel Aassane Kane, B. S. Ndaw, Awa Cheikh Diagne, Ndeytou Dieng, M. Sow, Maimouna Pouye, Abdoulaye
Copyright Year	2018
Abstract	L'insuffisance surrenalenne reste une pathologie tres peu decrite dans nos regions ; il s'agit d'une pathologie potentiellement mortelle en l'absence de traitement. Dans nos regions a forte endemicite tuberculeuse, les etiologies predominantes restent infectieuses ; les causes auto-immunes sont rarement decrites. Nous rapportons l'observation d'une patiente de 52ans suivie pour une insuffisance surrenalenne initialement sans etiologie retrouvee. Le diagnostic d'insuffisance surrenalenne d'origine auto-immune a ete retenu sur la base d'une baisse de la cortisolemie de 8 heures et la positivite des anticorps anti-21 alpha-hydroxylase. Le traitement repose sur la substitution en glucocorticoides associee a une substitution en mineralocorticoides. Les etiologies auto-immunes restent les causes predominantes dans les pays developpes et les algorithmes existants repondent a cette demarche. La recherche d'une pathologie infectieuse (VIH, tuberculose), de meme que la recherche d'autres maladies auto-immunes dans le cadre de polyendocrinopathies etaient negatives. Il devient necessaire d'etablir des algorithmes decisionnels adaptes a nos contextes surtout dans le cadre de la recherche etiologique. Mots cles : Anticorps anti-21 alpha-hydroxylase, Addisson, Glucocorticoides.
Starting Page	22
Ending Page	24
Page Count	3
File Format	PDF HTM / HTML
Volume Number	5
Alternate Webpage(s)	http://rafmi.org/index.php/rafmi/article/download/261/87
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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