Pomegranate Polyphenols and Resveratrol Protect the Neonatal Brain against Hypoxic-Ischemic Injury

Content Provider	Semantic Scholar
Author	West, Tim Atzeva, Madeliene Holtzman, David M.
Copyright Year	2007
Abstract	A previous study from our lab has shown that the polyphenol-rich pomegranate juice can protect the neonatal mouse brain against hypoxic-ischemic (H-I) injury when given to mothers in their drinking water. To test the hypothesis that this protection is due to the polyphenols in the juice, we studied the effects of the pomegranate polyphenol extract in the same neonatal H-I model. To further explore the role of a specific polyphenol in neonatal H-I we investigated the effects of resveratrol. The neuroprotective effects of resveratrol have been demonstrated in adult models of stroke, but had not previously been examined in neonates. We show that pomegranate polyphenols and resveratrol reduce caspase-3 activation following neonatal H-I. Resveratrol reduced caspase-3 activation when given before the injury but not when given 3 h after the injury. In addition to preventing caspase-3 activation, resveratrol also reduced calpain activation. Finally, we show that resveratrol can protect against tissue loss measured at 7 days after the injury. These and other recent findings suggest that polyphenols should be further investigated as a potential treatment to decrease brain injury due to neonatal H-I.
Starting Page	363
Ending Page	372
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1159/000105477
PubMed reference number	17762204
Journal	Medline
Volume Number	29
Alternate Webpage(s)	https://www.karger.com/article/pdf/105477
Alternate Webpage(s)	https://doi.org/10.1159/000105477
Journal	Developmental Neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article