Loading...
Please wait, while we are loading the content...
Similar Documents
Toward an integrated genetic and epigenetic approach to Alzheimer's disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mill, Jonathan |
| Copyright Year | 2011 |
| Abstract | Epigenetics is the study of mitotically heritable, but reversible, changes in gene expression brought about principally through alterations in DNA methylation and chromatin structure. The comprehensive review by Mastroeni et al. (Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P., Rogers, J., 2010. Epigenetic mechanisms in Alzheimer's disease. Neurobiol. Aging, doi:10.1016/j.neurobiolaging.2010.08.017) in this issue describes mounting evidence for an involvement of epigenetic alterations in the etiology of Alzheimer's disease (AD), highlighting the potential of epigenomic approaches for uncovering novel molecular pathways involved in pathology. Here, we briefly describe some methodological issues related to epigenomic studies using postmortem brain tissue in Alzheimer's disease, and argue for an integrated genetic-epigenetic approach to disease etiology. |
| Starting Page | 1188 |
| Ending Page | 1191 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neurobiolaging.2010.10.021 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0197458011000753 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0197458011000753?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | http://www.epigenomicslab.com/wp-content/uploads/publications/2011%20-%20Toward%20an%20integrated%20genetic%20and%20epigenetic%20approach%20to%20Alzheimer's%20disease.pdf |
| PubMed reference number | 21497948 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neurobiolaging.2010.10.021 |
| Journal | Medline |
| Volume Number | 32 |
| Journal | Neurobiology of Aging |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
