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Autophagy in neurodegeneration: two sides of the same coin.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Jin-A |
| Copyright Year | 2009 |
| Abstract | Autophagy is a bulk lysosomal degradation process important in development, differentiation and cellular homeostasis in multiple organs. Interestingly, neuronal survival is highly dependent on autophagy due to its post-mitotic nature, polarized morphology and active protein trafficking. A growing body of evidence now suggests that alteration or dysfunction of autophagy causes accumulation of abnormal proteins and/or damaged organelles, thereby leading to neurodegenerative disease. Although autophagy generally prevents neuronal cell death, it plays a protective or detrimental role in neurodegenerative disease depending on the environment. In this review, the two sides of autophagy will be discussed in the context of several neurodegenerative diseases. |
| File Format | PDF HTM / HTML |
| DOI | 10.5483/BMBRep.2009.42.6.324 |
| PubMed reference number | 19558789 |
| Journal | Medline |
| Volume Number | 42 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://ocean.kisti.re.kr/downfile/volume/ksbmb/E1MBB7/2009/v42n6/E1MBB7_2009_v42n6_324.pdf |
| Alternate Webpage(s) | http://dipbsf.uninsubria.it/labfarmaco/morte%20cellulare/review%20autofagia.pdf |
| Alternate Webpage(s) | https://doi.org/10.5483/BMBRep.2009.42.6.324 |
| Journal | BMB reports |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
