NDLI: [18F]AV‐1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

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[18F]AV‐1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

Content Provider	Semantic Scholar
Author	Jones, W. Richard Bevan Cope, Thomas Edmund Passamonti, Luca Fryer, Tim D. Young T. Aigbirhio, Franklin I. Kril, Jillian June Forrest, Shelley L. Allinson, Kieren S. J. Coles, Jonathan P. Jones, P. Simon Spillantini, Maria Grazia Hodges, John R. O'Brien, John T. Rowe, James Benedict
Copyright Year	2016
Abstract	The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease-modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV-1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of neuropathology seen in her father. Given the genetic diagnosis and the non-Alzheimer's pathology, these findings suggest that [18F]AV-1451 might be a useful biomarker in primary tauopathies. Largerscale in vivo and post-mortem studies will be needed to assess the technique's specificity.
Starting Page	940
Ending Page	947
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.repository.cam.ac.uk/bitstream/handle/1810/261165/BevanJones_et_al-2016-Annals_of_Clinical_and_Translational_Neurology-VoR.pdf;jsessionid=6AF02794A930723FCD5413EDC01E6629?sequence=1
PubMed reference number	28097206v1
Alternate Webpage(s)	https://doi.org/10.1002/acn3.366
DOI	10.1002/acn3.366
Journal	Annals of clinical and translational neurology
Volume Number	3
Language	English
Access Restriction	Open
Subject Keyword	Biological Markers Frontotemporal Lobar Degeneration Frontotemporal dementia Gene Mutation Hyperlipoproteinemia Type I MAPT gene Nerve Degeneration Patients TAU 3 Ag:PrThr:Pt:Tiss:Ord:Immune stain Tauopathies Therapeutic procedure neuropathology disease
Content Type	Text
Resource Type	Article

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