NDLI: B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice.

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B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice.

Content Provider	Semantic Scholar
Author	Major, Amy S. Fazio, Sergio Linton, Macrae F.
Copyright Year	2002
Abstract	OBJECTIVE Atherosclerosis is an inflammatory disease characterized by innate and adaptive immune responses. We investigated the role of B cells and antibodies in the development of atherosclerosis in low density lipoprotein (LDL) receptor-deficient (LDLR(-/-)) mice. METHODS AND RESULTS Using wild-type and B cell-deficient mice as bone marrow donors, we were able to generate LDLR(-/-) mice that possessed <1.0% of their normal B cell population. B cell-deficient LDLR(-/-) mice on a Western diet showed marked decreases in total serum antibody and anti-oxidized LDL antibody. B cell deficiency was associated with a 30% to 40% increase in the lesion area in the proximal and distal aortas. Real-time reverse transcription-polymerase chain reaction and enzyme-linked immunospot analyses showed a decrease in proatherogenic (interferon-gamma) and antiatherogenic (interleukin-10 and transforming growth factor-beta) cytokine mRNA and a decrease in interleukin-4- and interferon-gamma-producing cells. Additionally, we observed a decrease in splenocyte proliferation to oxidized LDL in the B cell-deficient LDLR(-/-) mice, suggesting that B lymphocytes may play a role in the presentation of lipid antigen. CONCLUSIONS Collectively, these data demonstrate that B cells and/or antibodies are protective against atherosclerosis and that this protection may be conferred by B cell-mediated immune regulation.
File Format	PDF HTM / HTML
DOI	10.1161/01.ATV.0000039169.47943.EE
PubMed reference number	12426221
Journal	Medline
Volume Number	22
Issue Number	11
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/22/11/1892.full.pdf
Alternate Webpage(s)	https://doi.org/10.1161/01.ATV.0000039169.47943.EE
Journal	Arteriosclerosis, thrombosis, and vascular biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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