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Release of alpha-melanocyte stimulating hormone into rat and human cerebrospinal fluid in vivo and from rat hypothalamus slices in vitro
| Content Provider | Semantic Scholar |
|---|---|
| Author | O'donohue, T. L. Charlton, Clivel G. Thoa, N. B. Helke, Cinda J. Jacobowitz, David M. |
| Copyright Year | 1981 |
| Abstract | The release of alpha-melanocyte stimulating hormone (alpha-MSH) from central nervous system neurons was investigated and demonstrated in vivo and in vitro. alpha-MSH immunoreactivity in rat and human cerebrospinal fluid (CSF) is comprised of deacetylated alpha-MSH, alpha-MSH and the methionine sulfoxide forms of these peptides. The sulfoxides are formed artifactually upon extraction. alpha-MSH in rat CSF is unaffected by hypophysectomy but is markedly increased by electrical stimulation of the mesencephalic central gray. These data indicate that CSF alpha-MSH is primarily of neuronal origin, alpha-MSH is also released in a calcium dependent manner from hypothalamic slices in vitro. The fact that the release of alpha-MSH is stimulated by veratridine and inhibited by tetrodotoxin demonstrates the necessity for neuronal sodium influx for alpha-MSH release. The presence of an alpha-MSH neurosecretory process supports a neurotropic role for this peptide in the central nervous system. |
| Starting Page | 93 |
| Ending Page | 100 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0196-9781(81)80017-4 |
| PubMed reference number | 7243627 |
| Journal | Medline |
| Volume Number | 2 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0196978181800174 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0196978181800174?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0196-9781%2881%2980017-4 |
| Journal | Peptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
