NDLI: Generalised osteoarthritis: a hormonally mediated disease.

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Generalised osteoarthritis: a hormonally mediated disease.

Content Provider	Semantic Scholar
Author	Spector, Tim D. Campion, Gianni
Copyright Year	1989
Abstract	A variety of clinical, pathological, and epidemiological data has suggested that generalised osteo-arthritis may be hormonally mediated. This article studies the available evidence and possible mechanisms involved. Osteoarthritis (OA) is a group of clinically heterogeneous disorders unified by the pathological features of hyaline cartilage loss and subchondral bone reaction. Population studies indicate the extremely high prevalence of OA (over the age of 70 up to 90% of the population have some radiological evidence of OA') and the sexual differences in its clinical presentation. Osteoarthritis in women more commonly affects multiple joints and is usually more severe than in men.' The apparent prominence of women presenting with polyarticular symptoms in middle age has fuelled speculation that there may be some relation between the onset of OA and the menopause. These ideas are not new; in 1805 Haygarth noted 'the nodosities of the joints are almost peculiar to women and begin when the menses naturally cease'.2 The term 'menopausal arthritis' was first coined as early as 1920 and has been given various synonyms, including climacteric arthritis, endocrine arthritis, hypoglandular arthritis, and chronic villous arthritis.
Starting Page	189
Ending Page	199
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ard.bmj.com/content/annrheumdis/48/6/523.full.pdf
PubMed reference number	2662920v1
Volume Number	48
Issue Number	6
Journal	Annals of the rheumatic diseases
Language	English
Access Restriction	Open
Subject Keyword	Bone Marrow Diseases Bone Tissue Degenerative polyarthritis Endocrine System Diseases Epidemiology Genetic Heterogeneity Hearing Loss, Mixed Conductive-Sensorineural Hyaline Cartilage Juvenile arthritis Juvenile rheumatoid arthritis Menopause Menstruation Middle Aged menopausal arthritis
Content Type	Text
Resource Type	Article

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