NDLI: Application of Metabolic Engineering to the Production of Scopolamine

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Application of Metabolic Engineering to the Production of Scopolamine

Content Provider	Semantic Scholar
Author	Palazón, Javier Navarro-Ocaña, Arturo Hernández-Vázquez, Liliana Mirjalili, Mohammad Hossein
Copyright Year	2008
Abstract	Scopolamine is an alkaloid widely used in medicine for its anticholinergic activity. The aim of this review is to show that metabolic engineering techniques constitute a suitable tool to improve the production of tropane alkaloids, focusing in particular on scopolamine. We present an overview of results obtained by various research groups, including our own, who have studied the overexpression of genes involved in the biosynthesis of scopolamine in different plant species that produce tropane alkaloids. Experiments carried out to improve production in hairy root cultures will also be described, as well as those attempting to biotransform hyoscyamine into scopolamine in roots and transgenic tobacco cells.
Starting Page	1722
Ending Page	1742
Page Count	21
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.mdpi.com/1420-3049/13/8/1722/pdf?y=1
Alternate Webpage(s)	http://www.mdpi.org/molecules/papers/13081722.pdf
Alternate Webpage(s)	http://www.mdpi.com/1420-3049/13/8/1722/pdf
PubMed reference number	18794782
Volume Number	13
Journal	Molecules
Language	English
Access Restriction	Open
Subject Keyword	Anabolism Anticholinergic Agents Brain Diseases, Metabolic Hyoscyamine Metabolic Engineering Plant Roots Rauwolfia Alkaloids Scopolamine Hydrobromide Secologanin Tryptamine Alkaloids Tropanes
Content Type	Text
Resource Type	Article

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