NDLI: Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites

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Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites

Content Provider	Semantic Scholar
Author	Yoshimura, Reiji Kishi, Taro Iwata, Nakao
Copyright Year	2019
Abstract	Objective IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD). Aim The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD. Participants and methods A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA. Results No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores. Conclusion No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.
Starting Page	2655
Ending Page	2661
Page Count	7
File Format	PDF HTM / HTML
DOI	10.2147/ndt.s195379
PubMed reference number	31686824
Journal	Medline
Volume Number	15
Alternate Webpage(s)	https://www.dovepress.com/getfile.php?fileID=52750
Alternate Webpage(s)	https://doi.org/10.2147/ndt.s195379
Journal	Neuropsychiatric disease and treatment
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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