NDLI: Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors.

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Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors.

Content Provider	Semantic Scholar
Author	Sakata, Takashi
Copyright Year	1987
Abstract	1. Effects of short-chain fatty acids (SCFA) on epithelial proliferation of the intestine were studied in ileally fistulated rats fed on an elemental diet. 2. The stimulatory effect of daily doses of acetic, propionic and n-butyric acids (100, 20 and 60 mM respectively; pH 6.1) per fistula (3 ml, twice daily) on crypt cell production rate (CCPR) appeared within 2 d and lasted for at least 5 d. 3. The daily doses of SCFA for 14 d increased daily CCPR three to four fold. This effect was independent of the presence of gut bacteria. 4. Effects of SCFA were dose-dependent and varied among acids (butyrate greater than propionate greater than acetate). The effect was independent of low lumen pH. 5. In contrast, SCFA inhibited epithelial proliferation of isolated rat caecal tissue in vitro. 6. These results suggest that SCFA are physiological lumen trophic factors mediated by a systemic mechanism in vivo. 7. It is concluded that SCFA are involved in the trophic effects of gut microbes, ingestion of fermentable fibre, and lumen contents.
Starting Page	95
Ending Page	103
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/4C8D8EA76B1DC2067DA50890BAE15638/S0007114587000758a.pdf/stimulatory_effect_of_shortchain_fatty_acids_on_epithelial_cell_proliferation_in_the_rat_intestine_a_possible_explanation_for_trophic_effects_of_fermentable_fibre_gut_microbes_and_luminal_trophic_factors.pdf
PubMed reference number	3620440v1
Volume Number	58
Issue Number	1
Journal	The British journal of nutrition
Language	English
Access Restriction	Open
Subject Keyword	Acetate Bacteria Butyrates Butyric Acids Cecum Cellular Phone Epithelial Cell Proliferation Fatty Acids Fatty Acids, Volatile Intestinal Wall Tissue Phenobarbital Propionates Structure of lumen of body system propionic
Content Type	Text
Resource Type	Article

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