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Spectrophotometric Determination of Primaquine by Coupling with Diazotized p-Nitroaniline Application to Pharmaceutical Formulations
| Content Provider | Semantic Scholar |
|---|---|
| Author | El-Samman, Ferial Mahmood Al-Irhayim, Asma Natiq Hamdoon, Enam Ahmed |
| Copyright Year | 2011 |
| Abstract | A simple spectrophotometric method for the determination of primaquine phosphate has been developed. The method is based on the coupling reaction of primaquine phosphate in acidic medium with diazotized p-nitroaniline, to form a yellow-orange water-soluble azo dye that shows maximum absorption at 482 nm. Beer' s law is obeyed over the concentration range 5-300 µg of primaquine phosphate in a final volum of� 25� ml, i.e., 0.2-12 ppm with a molar absorptivity of 6.610 4 l mol -1 cm -1 and Sandell' s sensitivity index of 0.0068 µg.cm -2 , a relative error of -0.63 to +0.32% and a relative standard deviation of ±0.18 to ±2.8%, depending on the concentration level. Interferences due to excipients have been examined. The proposed method has been applied to the assay of primaquine phosphate in pharmaceutical formulations (tablets). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.ceacsu.edu.pk/PDF%20file/Volume%2012%20No%201%20and%202/55-60.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
