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Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Trujillo, Marissa Hull-Crew, Clayton Outlaw, Andrew Stewart, Kevin Taylor, Loren George, Laura Duensing, Allison Tracey, Breanna Schoffstall, Allen |
| Copyright Year | 2019 |
| Abstract | Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,2,3-triazole products. The methods with Cu(I) catalysts were conventional, microwave heating, solvent-free, and a method using glycerol solvent. The compounds synthesized in this paper were known non-fluorinated triazoles and new fluorinated triazoles. The results lead to the conclusion that the microwave method should be strongly considered for CuAAC syntheses. |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/molecules24050973 |
| PubMed reference number | 30857343 |
| Journal | Medline |
| Volume Number | 24 |
| Alternate Webpage(s) | https://res.mdpi.com/molecules/molecules-24-00973/article_deploy/molecules-24-00973.pdf?attachment=1&filename= |
| Alternate Webpage(s) | https://doi.org/10.3390/molecules24050973 |
| Journal | Molecules |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
