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Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fisher, Patricia J. |
| Copyright Year | 2004 |
| Abstract | We have found that two-photon fluorescence imaging of nicotinamide adenine dinucleotide (NADH) provides the sensitivity and spatial three-dimensional resolution to resolve metabolic signatures in processes of astrocytes and neurons deep in highly scattering brain tissue slices. This functional imaging reveals spatiotemporal partitioning of glycolytic and oxidative metabolism between astrocytes and neurons during focal neural activity that establishes a unifying hypothesis for neurometabolic coupling in which early oxidative metabolism in neurons is eventually sustained by late activation of the astrocyte-neuron lactate shuttle. Our model integrates existing views of brain energy metabolism and is in accord with known macroscopic physiological changes in vivo. |
| Starting Page | 99 |
| Ending Page | 103 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://science.sciencemag.org/content/suppl/2004/07/01/305.5680.99.DC1/Kasischke.SOM.pdf |
| PubMed reference number | 15232110v1 |
| Volume Number | 305 |
| Issue Number | 5680 |
| Journal | Science |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Astrocytes Cell Respiration Dinucleoside Phosphates Energy Metabolism Fluorescence Imaging Functional Imaging Glycolysis Lactic acid Metabolic Process, Cellular NADH Neurons Niacinamide Nicotinamide adenine dinucleotide (NAD) Photons Precipitating Factors |
| Content Type | Text |
| Resource Type | Article |
