NDLI: Effect of Alcohol Consumption and Oxidative Stress and Its Role in DNA Damage

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Effect of Alcohol Consumption and Oxidative Stress and Its Role in DNA Damage

Content Provider	Semantic Scholar
Author	Deshpande, Neelesh Kandi, Sabitha
Copyright Year	2014
Abstract	Oxidative stress has been increasingly implicated in different stages of liver cirrhosis and has been found responsible for DNA damage. Alcohol consumption and oxidative stress have been linked with DNA damage and progression of disease, leading to the hypothesis that chronic alcoholism causes DNA damage. The study was aimed at evaluating the relation between alcohol consumption and relative oxidative damage in different stages of liver cirrhosis. The study included two groups based on severity of cirrhosis of liver; categorized as compensated and decompensated liver cirrhotic patients based on child Pugh criteria. All decompensated cirrhotic patients in the study group had significantly higher MDA levels (P < 0.001) associated with DNA Damage (P > 0.01) than those with compensated cirrhotic patients and control group who were not suffering from liver cirrhosis. These results highlighted a significant higher degree of DNA damage in decompensated cirrhotic patients associated with oxidative stress as shown from greater average DNA migration in decompensated cirrhotic patients than in the compensated cirrhotic patients with low level of oxidative stress. Thus these results suggest that increase in MDA levels may be associated with pathogenesis and progression of liver cirrhosis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://pubs.sciepub.com/ajbr/2/1/2/ajbr-2-1-2.pdf
Language	English
Access Restriction	Open
Subject Keyword	3,4-Methylenedioxyamphetamine Alcohol consumption Alcoholic Intoxication, Chronic Categorization Color gradient DNA Damage Ethanol 0.62 ML/ML Topical Gel Fibrosis Fibrosis, Liver Liver Cirrhosis Liver carcinoma Liver diseases Oxidative Stress Patients Tree accumulation
Content Type	Text
Resource Type	Article

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