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Clinical and virological significance of the co-existence of HBsAg and anti-HBs antibodies in hepatitis B chronic carriers.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Colson, Philippe Borentain, P. Motte, Anne Henry, Mireille Moal, Valérie Le Botta-Fridlund, Danielle Tamalet, Catherine Gérolami, René |
| Copyright Year | 2007 |
| Abstract | The co-existence of hepatitis B surface antigen (HBsAg) and anti-HBs antibodies (HBsAb) in serum of hepatitis B virus (HBV)-chronic carriers has been previously associated with HBsAg-amino acid (aa) substitutions. However, the aa pattern of HBV-reverse transcriptase (RT) and the clinical settings associated with this serological profile remain largely unknown. We studied thirteen HBsAg-positive/HBsAb-positive patients. Newly diagnosed HBsAg-positive/HBsAb-negative patients (n=51) served as controls. HBsAg/RT sequences were obtained using in-house protocols. HBsAg-positive/HBsAb-positive patients were predominantly immunosuppressed (69%). Five presented advanced liver fibrosis. HBV DNA >5.0 log(10) copies/ml was significantly more frequent than in controls. A significantly higher aa variability was observed versus controls within HBsAg major hydrophilic region (MHR), especially the a-determinant, and within RT for regions overlapping the MHR, the a-determinant, and HBsAg C terminal region where drug resistance mutations occur. Further studies are needed to determine whether this higher HBsAg/HBV-RT variability might favor dissemination of anti-HBsAb escape HBV mutants and concomitantly alter nucleos(t)ide analogs efficacy. |
| Starting Page | 30 |
| Ending Page | 40 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.virol.2007.05.012 |
| PubMed reference number | 17573090 |
| Journal | Medline |
| Volume Number | 367 |
| Issue Number | 1 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82240414.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.virol.2007.05.012 |
| Journal | Virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
