NDLI: New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function.

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New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function.

Content Provider	Semantic Scholar
Author	Perry, John R. B. Frayling, Timothy M.
Copyright Year	2008
Abstract	PURPOSE OF REVIEW Over the past 18 months, the number of gene loci robustly associated with type 2 diabetes has risen from three to 18. In this study, we focus on explaining the genome-wide approach that has led to most of these discoveries and discuss some of the early insights the new gene loci have provided into the aetiology of type 2 diabetes. RECENT FINDINGS Recent genome-wide association studies have provided an important resource for furthering our understanding of type 2 diabetes disease mechanisms. Genes previously unsuspected of playing a role in diabetes are now implicated in the disease process. These include genes in cell cycling control (CDKN2A/2B, CDKAL1), transcription factors (TCF7L2, HHEX), and ion channels (SLC30A8). These variants are all associated with insulin-secretory defects in the general population and show little if any relationship to insulin resistance. Two common variants (near or in FTO and MC4R) alter diabetes risk through a primary effect on obesity. SUMMARY Recent genome-wide association studies show that there are now 18 gene loci associated with the risk of type 2 diabetes. Most of these T2D gene loci affect insulin secretion.
Starting Page	IV16
Ending Page	IV29
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.t2diabetesgenes.org/Fraylinggrouppapers/PerryFrayling_T2DReview.pdf
PubMed reference number	18541994v1
Alternate Webpage(s)	https://doi.org/10.1097/MCO.0b013e32830349a1
DOI	10.1097/mco.0b013e32830349a1
Journal	Current opinion in clinical nutrition and metabolic care
Volume Number	11
Issue Number	4
Language	English
Access Restriction	Open
Subject Keyword	Cell physiology Cell secretion Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Non-Insulin-Dependent FTO gene HHEX gene Insulin Resistance Ion Channel Ions Transcription Factor 7-Like 2 insulin secretion
Content Type	Text
Resource Type	Article

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