Studi Potensi Interaksi Obat Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit Umum Daerah dr. Zainoel Abidin (RSUDZA) Banda Aceh

Content Provider	Semantic Scholar
Author	Sabella, Nazria
Copyright Year	2015
Abstract	Diabetes mellitus is a disease that affects many people and become a threat to humans because it can lead many complications. Overall cases of diabetes were mostly found, around 95% are type 2 diabetes mellitus. Most patients will receive treatment of diabetes mellitus by polypharmacy and it can affect the occurrence of drug interactions. Drug interaction is a one of drug related problem which identified as an occurance or state of drug therapy which able to affect patients clinic outcomes. This study aimed to determine whether there is of potential drug interactions in patients with diabetes mellitus type 2, determine the frequency of potential drug interactions in patients with diabetes mellitus type 2, and to determine whether the age and number of drugs can affect to potential drug interactions in patients with diabetes mellitus type 2. The study has been done on General Hospital dr. Zainoel Abidin Banda Aceh on November 2014 December 2014. The study was a descriptive Cross Sectional survey. Data were collected retrospectively from 196 sheets of recipes that meet the inclusion criteria. Data evaluation of drug interactions based on literatures of, Drug Interaction Fact, Stockley's Drug Interaction, Drug Fact & Comparisons, Adverse Drug Interaction A Handbook for Prescribers, A to Z Drug Facts and reliable internet sites (http://www.drugs.com/drug_interactions. html) and (http://www.medscape.com interaction checker). Data analysis has been done descriptively by using Chi-Square test on SPSS Advanced Statistics 16.0. The results showed that among 96 sheets of prescriptions found 123 prescriptions experienced the incidence of potential drug interactions with frequencies of potential interaction is 62.8%. The most interaction is the interaction of insulin and metformin were 46 cases (22.88%). Factors affecting the potential for drug interactions in patients with type 2 diabetes mellitus is the amount of drug (P = 0.000), whereas age was not associated with the occurrence of potential drug interaction (P = 0.890). Based on the result of this study, it can be concluded that the incidence of potential drug interactions in patients with diabetes mellitus type 2 is high with the majority of pharmacokinetic interaction mechanism is 42.29% for the moderate severity is about 64.68%, where about total drugs affect potential drug interactions.
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Alternate Webpage(s)	http://repository.usu.ac.id/bitstream/handle/123456789/52408/Cover.pdf;sequence=7
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article