Novas evidências sobre o valor diagnóstico da reação de imunofluorescência indireta e reação intradérmica de hipersensibilidade tardia na infecção humana por Leishmania (L.) infantum chagasi na Amazônia, Brasil

Content Provider	Semantic Scholar
Author	Barbosa, Raimundo Nonato Pires Correa, Zuíla De Jesus Coêlho Jesus, Roseli Conceição Dos Santos De Everdosa, Domingas Ribeiro Brandão, João Alves Coelho, R. Monteiro, Antonio Júlio De Oliveira Machado, Raimundo Sérgio Luz, João Batista Palheta Da Martins, Antonio Francisco Pires Brandão, Roberto Carlos Feitosa Lima, José Aprígio Nunes Barata, Iorlando Da Rocha Pinheiro, Maria Sueli Barros Leão, Edna De Freitas Silva, Fábio Márcio Medeiros Da Silva, Maria Das Graças Soares Campos, Marliane Batista Souza, Adelson Alcimar Almeida Lainson, Ralph Silveira, Fernando Tobias
Copyright Year	2010
Abstract	This is a prospective study on a cohort of 1099 individuals of both genders, aged 1-84 years (mean 24.4 years), living in an endemic area of American visceral leishmaniasis (AVL) in the Municipality of Cametá, Brazil, from May 2006 to September 2008. It aimed to analyze the prevalence and incidence rates of human infection by Leishmania (L.) infantum chagasi, as well as the evolutional process of its previously defined clinical and immunological profiles: 1. Asymptomatic infection (AI); 2. Symptomatic infection (SI = AVL); 3. Subclinical oligosymptomatic infection (SOI); 4. Subclinical resistant infection (SRI); and 5. Indeterminate initial infection (III). The diagnosis was based on the simultaneous use of indirect immunofluorescence assay (IFA) and delayed hypersensitivity skin test. A total of 304 cases of infection were diagnosed during the period studied (187 for prevalence and 117 for incidence), generating an accumulated prevalence rate of 27.6%. The distribution regarding their clinical and immunological profiles presented the following order: AI 51.6%; III 22.4 %; SRI 20.1%; SOI 4.3%; and SI (= AVL) 1.6%. Based on the dynamics of the infection, the main discovery was about the III profile, which had an instrumental role in its evolution, directing it either to the resistant immunological pole – SRI (21 cases 30.8%) and AI (30 cases 44.1 %) profiles – or to the susceptible immunological pole – SI (1 case 1.5%) profile. In addition, 16 cases remained within the III profile until the end of the study. It was concluded that this diagnostic approach can help monitor the infection in endemic areas, aiming mainly at preventing morbidity caused by AVL, and reducing the treatment time and expenses.
Starting Page	33
Ending Page	44
Page Count	12
File Format	PDF HTM / HTML
DOI	10.5123/S2176-62232010000100006
Volume Number	1
Alternate Webpage(s)	http://scielo.iec.gov.br/pdf/rpas/v1n1/v1n1a06.pdf
Alternate Webpage(s)	http://scielo.iec.gov.br/pdf/rpas/v1n1/es_v1n1a06.pdf
Alternate Webpage(s)	https://doi.org/10.5123/S2176-62232010000100006
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article