Investigation of serum BDNF levels in drug-naive patients with schizophrenia

Content Provider	Semantic Scholar
Author	Rizos, E. N. Rontos, Ioannis Laskos, Efstathios Arsenis, George Lykouras, Lefteris
Copyright Year	2008
Abstract	The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate the neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Decreased BDNF levels in the brain and the serum of patients with psychotic disorders have been reported. In the present study, we assessed serum BDNF levels in a group of 14 drug-naive first-episode patients with schizophrenia (FEP), compared to 15 healthy controls. The serum BDNF levels in the sample of FEP patients was significantly reduced compared to normal controls (23.92+/-5.99 ng/ml vs. 30.0+/-8.43 ng/ml, F=5.01, df=1, p=.034). Negative correlations were shown between serum BDNF levels of the patients and the PANSS Positive and Negative subscale scores. Our findings indicate that BDNF levels at the onset of schizophrenia may reflect associated pathophysiological processes as well as the severity of positive and negative psychotic symptoms.
Starting Page	1308
Ending Page	1311
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/j.pnpbp.2008.04.007
PubMed reference number	18502013
Journal	Medline
Volume Number	32
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0278584608001097
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0278584608001097?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.pnpbp.2008.04.007
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article