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Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wiik, Benedicte Pran Larstorp, Anne Cecilie Kjeldsen Høieggen, Aud Kjeldsen, Sverre Erik Olsen, Mirjam Harkestad Ibsen, H. L. Lindholm, Lars Dahlöf, Björn Devereux, Richard Blyton Okin, P. A. Wachtell, Kristian |
| Copyright Year | 2010 |
| Abstract | BACKGROUND It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS In the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, a double-masked, parallel-group design, 9,193 patients with hypertension and electrocardiographic LVH were randomized to losartan- or atenolol-based antihypertensive treatment and followed for a mean of 4.9 years. At baseline, 7,489 patients with available SUA measurements did not have diabetes mellitus and were thus at risk of its development during the study. We used Cox regression analyses to investigate whether SUA predicted development of NOD. RESULTS NOD developed in 522 of 7,489 patients. The association between baseline SUA and development of NOD was significant (hazard ratio (HR) 1.29 per s.d. (1.3 mg/dl), 95% confidence interval (CI) 1.18-1.42, P < 0.001) after adjustment for treatment with losartan vs. atenolol, baseline serum glucose, urinary albumin/creatinine ratio, estimated glomerular filtration rate and Framingham risk score, time-varying systolic and diastolic blood pressure, and time-varying LVH by Cornell voltage-duration product and Sokolow-Lyon voltage. In parallel analyses, baseline quartiles of SUA were significantly associated with increasing NOD (HR 1.28, 95% CI 1.18-1.40, P < 0.001). Time-varying SUA was also associated with NOD (HR 1.10 per s.d. [1.3 mg/dl], 95% CI 1.02-1.19, P = 0.015). CONCLUSION Our analysis suggests that SUA is an independent risk marker for NOD in hypertensive patients with LVH. |
| Starting Page | 34 |
| Ending Page | 45 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/30899827.pdf |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ajh/23/8/10.1038_ajh.2010.89/1/23_8_845.pdf?Expires=1492218918&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=PfZGNeSMYQJi8lpDEYT6cniZ8VC1t~nv6~3qs6y6gAZsZBOnhiA8WM2VH9xlgXd7~h7dcZL~EKfAHx9TbZQLuabR4qW40QosUk-x2U5uLuSzz~kQ0IwR3m1~ihqNblC3JWQkL8HqHORJHKszpXCNJ8NSnpHReLH7YU6sE3PeWetoxc~~Qt5rUT3uFpMPLqdD6SsA~GVyaLlc733dPpEJsFjp3212BZUIXINlXzGMs257jMA4nQYDp-07mJJcbE9tf1lWbr0F1DxSBEwP6pvki67Fg7Ita4z4vCye0~hKopnQD~AJF3FyhCaW-hjWGwswpoKIZoptyp0KXh1cfmFJiQ__ |
| PubMed reference number | 20431530v1 |
| Alternate Webpage(s) | https://doi.org/10.1038/ajh.2010.89 |
| DOI | 10.1038/ajh.2010.89 |
| Journal | American journal of hypertension |
| Volume Number | 23 |
| Issue Number | 8 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antihypertensive Agents Atenolol BaseLine dental cement Confidence Intervals Creatinine Diabetes Mellitus Diastole Hypertensive disease Left Ventricular Hypertrophy Losartan Mice, Inbred NOD Microalbumin Patients Regression Analysis Serum urate measurement Treatment - Filtration Uric Acid glomerular filtration mg/dl serum glucose voltage |
| Content Type | Text |
| Resource Type | Article |
