NDLI: Gunstig langetermijneffect bij responders op interferonbehandeling onder patiënten met chronische hepatitis B in vergelijking tot non-responders; retrospectief onderzoek

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Gunstig langetermijneffect bij responders op interferonbehandeling onder patiënten met chronische hepatitis B in vergelijking tot non-responders; retrospectief onderzoek

Content Provider	Semantic Scholar
Author	Zonneveld, Monika Van Honkoop, Pieter Hansen, Bettina E. Niesters, Hubert G. M. Murad, Sarwa Darwish Schalm, Solko W. Janssen, Hla
Copyright Year	2005
Abstract	Objective. To evaluate factors that influence clinical outcome and survival in chronic hepatitis-B patients treated with interferon alpha (IFNa). Design. Retrospective. Method. In a follow-up study of I65 hepatitis B e antigen (HBeAg)-positive patients who had been treated with IFNa in Rotterdam, the Netherlands, in I978-2002, data were collected on general patient characteristics, immunologic response, viral load, alanine aminotransferase (ALAT) activity, liver histology, occurrence of decompensated cirrhosis and hepatocellular carcinoma, and survival. Results. Median follow-up was 8.8 years (range: 0.3-23.9). 54 patients (33%) responded to IFNα treatment, defined as HBeAg loss within 12 months after the end of IFNa therapy. 52 percent of the responders lost hepatitis B surface antigen (HBsAg) as compared to 9% of the non-responders (p < 0.00I). Liver histology showed a decreased inflammatory activity and less progression of fibrosis in responders. Hepatocellular carcinoma was found in 8 patients, of whom 6 were non-responders. Of the 2 responders that developed hepatocellular carcinoma, I had relapsed after discontinuation of therapy. Multivariate analysis showed a significantly improved survival (relative risk (RR) of death: 0.28; 95% CI: 0.I0-0.78) and reduced risk of developing hepatocellular carcinoma (RR: 0.084; 95% CI: 0.0I-0.75) in responders. Conclusion. Response to IFNa therapy resulted in a prolonged clinical remission with an increased rate ofHBsAg seroconversion and improved liver histology. After correction for baseline factors, response to IFNα therapy was associated with increased survival and a reduced risk of developing hepatocellular carcinoma.
Starting Page	1510
Ending Page	1515
Page Count	6
File Format	PDF HTM / HTML
Volume Number	149
Alternate Webpage(s)	https://www.ntvg.nl/system/files/publications/2005115100001a.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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