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Expansion of CD 4 + CD 25 + Foxp 3 + regulatory T cells in vitro and application in graft-versus-host disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tao, Feng Jie, Yang Hua-Hua, Fan |
| Copyright Year | 2013 |
| Abstract | Allogeneic hematopoietic stem cell transplantation is an important way to control acute and chronic leukemia and other hematological malignancies, but acute and chronic graft-versus-host diseases (GVHD), which are major complications in the allogeneic hematopoietic stem cell transplantation influence the survival rate severely, and restrict the clinical application of transplantation. A great number of studies found that CD4CD25 regulatory T cells(Treg cell) expressing Foxp3 highly are potential in controlling acute and chronic GVHD, and do not weaken graft versus leukemia(GVL). It plays an important role in acute and chronic GVHD generation, development and therapy. However, the proportion of Treg cell in vivo is very small, so it can not meet the clinical requirements. At present, most experiments utilize exogenous IL-2 and TCR, CD28 signaling pathway to expand Treg cells in vitro. In addition, dendritic cells can induce Treg cells proliferation effectively in vivo and in vitro. These expended Treg cells exert significant effect in control acute and chronic GVHD, as well as the prevention and suppression of autoimmune diseases and transplant rejection, and have broad prospects in disease control and clinical application. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.lifescience.net.cn/news/upload/2009156.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
