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Chronic Intracortical Recording and Electrochemical Stability of Thiol-ene/Acrylate Shape Memory Polymer Electrode Arrays
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stiller, Allison M. Usoro, Joshua Frewin, Christopher L. Danda, Vindhya Reddy Ecker, Melanie Joshi-Imre, Alexandra Musselman, Kate C. Voit, Walter E. Modi, Romil Pancrazio, Joseph J. Black, Bryan James |
| Copyright Year | 2018 |
| Abstract | Current intracortical probe technology is limited in clinical implementation due to the short functional lifetime of implanted devices. Devices often fail several months to years post-implantation, likely due to the chronic immune response characterized by glial scarring and neuronal dieback. It has been demonstrated that this neuroinflammatory response is influenced by the mechanical mismatch between stiff devices and the soft brain tissue, spurring interest in the use of softer polymer materials for probe encapsulation. Here, we demonstrate stable recordings and electrochemical properties obtained from fully encapsulated shape memory polymer (SMP) intracortical electrodes implanted in the rat motor cortex for 13 weeks. SMPs are a class of material that exhibit modulus changes when exposed to specific conditions. The formulation used in these devices softens by an order of magnitude after implantation compared to its dry, room-temperature modulus of ~2 GPa. |
| File Format | PDF HTM / HTML |
| DOI | 10.3390/mi9100500 |
| PubMed reference number | 30424433 |
| Journal | Medline |
| Volume Number | 9 |
| Alternate Webpage(s) | https://www.mdpi.com/2072-666X/9/10/500/pdf/1 |
| Alternate Webpage(s) | https://res.mdpi.com/micromachines/micromachines-09-00500/article_deploy/micromachines-09-00500.pdf?attachment=1&filename= |
| Alternate Webpage(s) | https://doi.org/10.3390/mi9100500 |
| Journal | Micromachines |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
