Interaction of endostatin with integrins implicated in angiogenesis.

Content Provider	Semantic Scholar
Author	Rehn, Matilda Veikkola, Tanja Kukk-Valdre, E. Nakamura, Hideki Ilmonen, Maritta Lombardo, Claudia Pihlajaniemi, Taina Alitalo, Kari Vuori, Kristiina
Copyright Year	2001
Abstract	Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with alpha(5)- and alpha(v)-integrins on the surface of human endothelial cells. We further demonstrate that the endostatin-integrin interaction is of functional significance in vitro, as we found that immobilized endostatin supports endothelial cell survival and migration in an integrin-dependent manner. Soluble endostatin in turn inhibits integrin-dependent endothelial cell functions, such as cell migration. Taken together, these results implicate integrins as potential targets for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.98.3.1024
PubMed reference number	11158588
Journal	Medline
Volume Number	98
Issue Number	3
Alternate Webpage(s)	http://www.pnas.org/content/98/3/1024.full.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.98.3.1024
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article