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Structure-based design of inhibitors of purine nucleoside phosphorylase.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Babu, Yarlagadda S. Ealick, Steven E. Bugg, Charles E. Erion, Mark D. Guida, Wayne C. Montgomery, John A. Secrist, John A. |
| Copyright Year | 1995 |
| Abstract | Inhibitors of purine nucleoside phosphorylase may have therapeutic value in the treatment of T-cell proliferative diseases such as T-cell leukemia, in the suppression of host-versus-graft response in organ transplants, and in the treatment of T-cell-mediated autoimmune diseases. Competitive inhibitors of this enzyme have been designed using the three-dimensional structure of the enzyme determined by X-ray crystallography. This approach has resulted in the synthesis of the most potent and membrane-permeable inhibitors of purine nucleoside phosphorylase reported so far. |
| File Format | PDF HTM / HTML |
| DOI | 10.1107/S0907444994011704 |
| Alternate Webpage(s) | http://journals.iucr.org/d/issues/1995/04/00/gr0515/gr0515.pdf |
| PubMed reference number | 15299840 |
| Alternate Webpage(s) | https://doi.org/10.1107/S0907444994011704 |
| Journal | Medline |
| Volume Number | 51 |
| Part | 4 |
| Journal | Acta crystallographica. Section D, Biological crystallography |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
