Synthesis of Flavone Derivatives through Versatile Palladium-Catalyzed Cross-Coupling Reactions of Tosyloxy- and Mesyloxyflavones

Content Provider	Semantic Scholar
Author	Pang, Wai Hang Chen, Xiangmeng Chen, Zi-Cong Kwong, Fuk Yee So, Chau Ming
Copyright Year	2019
Abstract	Tosyloxy- and mesyloxyflavones derived from abundant and biologically important hydroxyflavones were used to synthesize a series of functionalized flavones through versatile palladium-catalyzed cross-coupling reactions. A Pd(OAc)2/2-[2-(dicyclohexylphosphino)phenyl]-1-methyl-1H-indole system effectively catalyzed the reactions of a broad range of tosyloxy- and mesyloxyflavones as electrophilic coupling partners with various nucleophiles to give the corresponding products in good to excellent yields. Catalyst loadings of as little as 0.1 mol% Pd were successfully used. Importantly, we demonstrated that this protocol provided a significantly improved efficiency in the synthesis of a potential chromen-4-one-based analogue of a potent inhibitor of DNA-dependent protein kinase.
Starting Page	731
Ending Page	737
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1055/s-0037-1611742
Volume Number	30
Alternate Webpage(s)	https://www.thieme-connect.de/media/synlett/201906/supmat/sup_st-2019-u0040-l_10-1055_s-0037-1611742.pdf
Alternate Webpage(s)	https://doi.org/10.1055/s-0037-1611742
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article