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A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Qiu, Liping Chen, Tao Öçsoy, Ismail Yasun, Emir Wu, Cuichen Zhu, Guizhi You, Mingxu Han, Da Cheng Jiang, Jianhui Yu, Ruqin Tan, Weihong |
| Copyright Year | 2015 |
| Abstract | The development of multidrug resistance (MDR) has become an increasingly serious problem in cancer therapy. The cell-membrane overexpression of P-glycoprotein (P-gp), which can actively efflux various anticancer drugs from the cell, is a major mechanism of MDR. Nuclear-uptake nanodrug delivery systems, which enable intranuclear release of anticancer drugs, are expected to address this challenge by bypassing P-gp. However, before entering the nucleus, the nanocarrier must pass through the cell membrane, necessitating coordination between intracellular and intranuclear delivery. To accommodate this requirement, we have used DNA self-assembly to develop a nuclear-uptake nanodrug system carried by a cell-targeted near-infrared (NIR)-responsive nanotruck for drug-resistant cancer therapy. Via DNA hybridization, small drug-loaded gold nanoparticles (termed nanodrugs) can self-assemble onto the side face of a silver-gold nanorod (NR, termed nanotruck) whose end faces were modified with a cell type-specific internalizing aptamer. By using this size-photocontrollable nanodrug delivery system, anticancer drugs can be efficiently accumulated in the nuclei to effectively kill the cancer cells. |
| Starting Page | 457 |
| Ending Page | 463 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/nl503777s |
| PubMed reference number | 25479133 |
| Journal | Medline |
| Volume Number | 15 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/8a/ce/nl503777s.PMC4296921.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/nl503777s |
| Journal | Nano letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
