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Light- and electron-microscopic analysis of neuropeptide Y-immunoreactive amacrine cells in the guinea pig retina
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kang, Wha-Sun Lim, Min-Young Lee, Eun-Jin Kim, In-Beom Brecha, Nicholas C. Park, Cheol-Beom Chun, Myung-Hoon |
| Copyright Year | 2014 |
| Abstract | We investigated the morphology and synaptic connections of neuropeptide Y (NPY)-containing neurons in the guinea pig retina by immunocytochemistry, using antisera against NPY. Specific NPY immunoreactivity was localized to a population of wide-field and regularly spaced amacrine cells with processes ramifying mainly in stratum 1 of the inner plexiform layer (IPL). Double-label immunohistochemistry demonstrated that all NPY-immunoreactive cells possessed glutamic acid decarboxylase 65 immunoreactivity. The synaptic connectivity of NPY-immunoreactive amacrine cells was identified in the IPL by electron microscopy. The NPY-labeled amacrine cell processes received synaptic input from other amacrine cell processes and bipolar cell axon terminals in stratum 1 of the IPL. The most frequent postsynaptic targets of NPY-immunoreactive amacrine cells were other amacrine cell processes. Synaptic outputs to bipolar cells were also observed in a small number of cases. This finding suggests that NPY-containing amacrine cells may influence inner retinal circuitry in stratum 1 of the IPL, thus mediating visual processing. |
| Starting Page | 363 |
| Ending Page | 371 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s004410100460 |
| PubMed reference number | 11735036 |
| Journal | Medline |
| Volume Number | 306 |
| Alternate Webpage(s) | http://vpl.usc.edu/files/2013/07/Kang_et_al_2001_neuropeptide1.pdf |
| Alternate Webpage(s) | http://vpl.usc.edu/files/2013/07/Kang_et_al_2001_neuropeptide.pdf |
| Alternate Webpage(s) | https://vpl.usc.edu/files/2013/07/Kang_et_al_2001_neuropeptide.pdf |
| Alternate Webpage(s) | https://vpl.usc.edu/files/2013/07/Kang_et_al_2001_neuropeptide1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s004410100460 |
| Journal | Cell and Tissue Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
