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Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhong, Jian Liu, Daoyan Ni, Yinxing Zhao, Zhigang Zhu, Shanjun Tepel, Martin Zhu, Zhiming |
| Copyright Year | 2006 |
| Abstract | To establish whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry the GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (P = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; P = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome. |
| Starting Page | 91 |
| Ending Page | 95 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.lab.2005.10.001 |
| PubMed reference number | 16459167 |
| Journal | Medline |
| Volume Number | 147 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0022214305003495 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0022214305003495 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.lab.2005.10.001 |
| Journal | Journal of Laboratory and Clinical Medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
