Amphetamine-induced release of dopamine from the substantia nigra in vitro.

Content Provider	Semantic Scholar
Author	Paden, Charles M. Wilson, Charles J. Groves, Philip M.
Copyright Year	1976
Abstract	Abstract Incubation of chopped tissue from the substantia nigra of the rat brain with d-amphetamine resulted in a significant release of [ 3 H]dopamine into the incubation medium. This effect was observed with both exogenous [ 3 H]dopamine previously taken up by the tissue and [ 3 H]dopamine endogenously synthesized from L-[3,5- 3 H]tyrosine. The observed release was greater in magnitude when the apparent conversion of released dopamine to 3-methoxytyramine was taken into account. The relevance of the present results to the previously postulated self-inhibition by dopaminergic neurons of the substantia nigra pars compacta is discussed. The present data also provide support for the concept that catechol-O-methyltransferase (E.C.2.1.1.6.) is located primarily extraneuronally in brain.
File Format	PDF HTM / HTML
DOI	10.1016/0024-3205(76)90094-1
PubMed reference number	994699
Journal	Medline
Volume Number	19
Issue Number	10
Alternate Webpage(s)	http://marlin.life.utsa.edu/bibliopdfs/PWG76.pdf
Alternate Webpage(s)	https://doi.org/10.1016/0024-3205%2876%2990094-1
Journal	Life sciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article