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Three human transforming genes are related to the viral ras oncogenes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimizu, Katsuhiko Goldfarb, Mitchell Suard, Yolande Perucho, Manuel Li, Yuhua Kamata, Tohru Feramisco, James R. Stavnezer, Edward Fogh, Jørgen Wigler, Michael |
| Copyright Year | 1983 |
| Abstract | Three distinct transforming genes present in human tumor cell lines are all related to the viral oncogenes of Harvey and Kirsten murine sarcoma viruses, designated v-H-ras and v-K-ras, respectively. The transforming gene of a bladder carcinoma cell line has been shown to be a human homolog to v-H-ras [Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. (1982) Nature (London) 297, 474-478; Santos, E., Tronick, S. R., Aaronson, S. A., Pulciani, S. & Barbacid, M. (1982) Nature (London) 298, 343-347]. The transforming gene common to one colon (SK-CO-1) and two lung carcinoma (SK-LU-1 and Calu-1) cell lines is the same human homolog of v-K-ras as is the transforming gene previously identified in a lung carcinoma cell line Lx-1 [Der, C. J., Krontiris, T. G. & Cooper, G. M. (1982) Proc. Natl. Acad. Sci. USA 79, 3637-3640]. The transforming gene of SK-N-SH neuroblastoma cells is weakly homologous to both v-H-ras and v-K-ras. NIH 3T3 cells transformed with the SK-N-SH transforming gene contain increased levels of a protein serologically and structurally related to the protein products of the v-H-ras and v-K-ras genes. Therefore, it represents a third member of the ras gene family, which we have called N-ras. Based on the homology with the v-ras genes, we have established the orientation of transcription and approximate coding regions of the cloned human K-ras and N-ras genes. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.80.8.2112 |
| PubMed reference number | 6572964 |
| Journal | Medline |
| Volume Number | 80 |
| Issue Number | 8 |
| Alternate Webpage(s) | http://wigserv2.cshl.edu/lib/exe/fetch.php?media=shimizu_et_at_pnas_1983.pdf |
| Alternate Webpage(s) | http://repository.cshl.edu/26007/1/Wigler_PNAS_1983three.pdf |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.80.8.2112 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
