NDLI: Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke uptake parameters

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Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke uptake parameters

Content Provider	Semantic Scholar
Author	Muranaka, H. Higashi, Eriko Itani, S. M. Shimizu, Yoshinori
Copyright Year	1988
Abstract	SummaryIn a cross-sectional study on 236 individuals in Japan (174 males, 62 females; 149 smokers, 87 non-smokers) plasma nicotine (pnic), cotinine (pcot) and thiocyanate (pSCN), urinary creatinine ratios of nicotine (unic), cotinine (ucot) and thiocyanate (uSCN) as well as carboxyhemoglobin (COHb) and expired carbon monoxide (COex) were determined. All tobacco smoke uptake parameters (TSUP) were significantly elevated in smokers as compared to non-smokers. The discriminant power (smokers vs non-smokers) rank in the following order: ucot ∼ pcot ∼ unic > pSCN ∼ COHb ∼ pnic > COex ∼ uSCN. All parameters except for pnic are significantly correlated with the self-reported number of cigarettes smoked per day. The reason for the poor correlation of pnic with daily cigarette consumption is the short half-life of pnic coupled with the arbitrary time of blood drawing in relation to the last time of smoking.
Starting Page	37
Ending Page	41
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1007/BF00409377
Alternate Webpage(s)	https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF00409377
PubMed reference number	3258284
Alternate Webpage(s)	https://doi.org/10.1007/BF00409377
Journal	Medline
Volume Number	60
Journal	International archives of occupational and environmental health
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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