Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained simulation of the perforant path

Content Provider	Semantic Scholar
Author	Ylinen, Aarne Valjakka, Antti Lahtinen, H. Miettinen, Riitta Riekkinen, Paavo
Copyright Year	1991
Abstract	Somatostatin-containing neurons in the hilus of the dentate gyrus are known to be exceptionally vulnerable in experimental models of epilepsy, as well as in human temporal lobe epilepsy. The position of these cells in the circuitry of the dentate gyrus is ideal for gating the activation evoked by afferents from the entorhinal cortex. In the present study we have shown that the loss of hilar somatostatin-containing neurons, and the development of interictal spiking activity induced by sustained perforant pathway stimulation can be prevented by high doses (500 mg/kg), but not by low doses (100 mg/kg) of vigabatrin, an irreversible inhibitor of GABA-transaminase.
Starting Page	205
Ending Page	211
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/0143-4179(91)90120-8
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0143417991901208
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0143417991901208?dgcid=api_sd_search-api-endpoint
PubMed reference number	1680224
Alternate Webpage(s)	https://doi.org/10.1016/0143-4179%2891%2990120-8
Journal	Medline
Volume Number	19
Journal	Neuropeptides
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article