NDLI: 3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs.

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3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs.

Content Provider	Semantic Scholar
Author	Knowlton, Stephanie Yu, Chu Hsiang Ersoy, Fulya Emadi, Sharareh Khademhosseini, Ali Tasoglu, Savas
Copyright Year	2016
Abstract	Three-dimensional (3D) printing offers potential to fabricate high-throughput and low-cost fabrication of microfluidic devices as a promising alternative to traditional techniques which enables efficient design iterations in the development stage. In this study, we demonstrate a single-step fabrication of a 3D transparent microfluidic chip using two alternative techniques: a stereolithography-based desktop 3D printer and a two-step fabrication using an industrial 3D printer based on polyjet technology. This method, compared to conventional fabrication using relatively expensive materials and labor-intensive processes, presents a low-cost, rapid prototyping technique to print functional 3D microfluidic chips. We enhance the capabilities of 3D-printed microfluidic devices by coupling 3D cell encapsulation and spatial patterning within photocrosslinkable gelatin methacryloyl (GelMA). The platform presented here serves as a 3D culture environment for long-term cell culture and growth. Furthermore, we have demonstrated the ability to print complex 3D microfluidic channels to create predictable and controllable fluid flow regimes. Here, we demonstrate the novel use of 3D-printed microfluidic chips as controllable 3D cell culture environments, advancing the applicability of 3D printing to engineering physiological systems for future applications in bioengineering.
Starting Page	025019
Ending Page	025019
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1088/1758-5090/8/2/025019
PubMed reference number	27321481
Journal	Medline
Volume Number	8
Issue Number	2
Alternate Webpage(s)	https://tasoglulab.net/uploads/3/4/8/2/34824429/bf_8_2_025019.pdf
Alternate Webpage(s)	https://doi.org/10.1088/1758-5090%2F8%2F2%2F025019
Journal	Biofabrication
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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