102. Prenatal stress, depression, and herpes viral reactivation

Content Provider	Semantic Scholar
Author	Hsu, Patrick Groer, Maureen Wang, Shu-Ching Williams, Stephanie N. Kane, Bradley P.
Copyright Year	2013
Abstract	Psychosocial stress is a predictor of prenatal depression. Prenatal depression may be associated with herpes viral reactivation. The purpose of this study was to analyze relationships among prenatal stress, depression, herpes viral titers, and metabolites of indoleamine-2, 3-dioxygenase (IDO) activation, an enzyme that is highly upregulated in pregnancy. IDO activation decreases tryptophan production and increases phenylalanine/tyrosine metabolism, respectively. Prenatal depression may occur from tryptophan stealing through the IDO pathway which results in decreased serotonin and increased risk for latent viral reactivation. Participants ( N = 382) were between 16 to 25 gestational weeks. The data included demographics, Perceived Stress Scale, and Profile of Mood States scores. The plasma was analyzed for HSV-1 and HSV-2 IgG, CMV IgG and nitrite, neopterin, tryptophan, kynurenine, phenylalanine, and tyrosine. Perceived stress was correlated with depressive symptoms. Depressive symptoms were correlated with HSV-2 IgG titer ( r = .215, p
Starting Page	e29
Ending Page	e30
Page Count	2
File Format	PDF HTM / HTML
DOI	10.1016/j.bbi.2013.07.114
Volume Number	32
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0889159113003486
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0889159113003486?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.bbi.2013.07.114
Journal	Brain, Behavior, and Immunity
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article