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Pulmonary and sinus diseases in primary humoral immunodeficiencies with chronic productive cough.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rusconi, Franca Panisi, C. Dellepiane, Rosa Maria Cardinale, Francesco Chini, Lorenza Martire, Baldassarre Bonelli, Nicola Felisati, Giovanni Pietrogrande, Maria Cristina |
| Copyright Year | 2003 |
| Abstract | AIMS To prospectively evaluate sinopulmonary disease in 24 patients with primary humoral immunodeficiency (11 with agammaglobulinaemia, nine with isolated IgA deficiency, and two with common variable immunodeficiency) and chronic productive cough, ascertain the usefulness of chest high resolution computed tomography (HRCT) in evaluating the progression of lung disease, and test a therapeutic approach to chronic sinusitis. METHODS Pulmonary abnormalities were evaluated using lung function tests and HRCT (Bhalla score); chronic sinusitis was diagnosed clinically and confirmed by flexible fibreoptic endoscopy. Sixteen patients entered the three year follow up. RESULTS Lung function testing revealed an obstruction in four patients; chest HRCT was abnormal in 16. There was a linear relation between the Bhalla score > or =4 and the number of months with cough/year over the previous two years (clinical score), and between the difference in clinical scores during follow up and in the previous two years and the difference in Bhalla score. The pulmonary lesions did not significantly progress over a three year period. Thirteen patients had chronic sinusitis; 6/10 patients followed up were successfully treated with antibiotics plus topical therapy and two with nasal polypoid disease with endoscopic sinus surgery. CONCLUSIONS In patients with primary humoral immunodeficiency and chronic productive cough, HRCT is very useful in delineating the extent of lung damage. The correlation between Bhalla score and clinical findings and the favourable outcome of the disease suggests that in most patients chest HRCT should not be repeated annually as previously suggested. Medical therapy seems to be effective in many cases of chronic sinusitis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://adc.bmj.com/content/archdischild/88/12/1101.full.pdf |
| PubMed reference number | 14670780v1 |
| Volume Number | 88 |
| Issue Number | 12 |
| Journal | Archives of disease in childhood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Addison Disease Agammaglobulinemia Chronic sinusitis Common Variable Immunodeficiency Congenital Abnormality Coughing High Resolution Computed Tomography Idiopathic Pulmonary Fibrosis Immunoglobulin A deficiency (disorder) Immunologic Deficiency Syndromes Lung diseases Nasal sinus Obstruction Patients Respiratory physiology Signs and Symptoms Structure of parenchyma of lung X-Linked Combined Immunodeficiency Diseases X-Ray Computed Tomography productive cough |
| Content Type | Text |
| Resource Type | Article |
