NDLI: The Effect of Drinking on Plasma Vasopressin and Renin in Dehydrated Human Subjects

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The Effect of Drinking on Plasma Vasopressin and Renin in Dehydrated Human Subjects

Content Provider	Semantic Scholar
Author	Geelen, Ghislaine Keil, Lanny C. Kravik, Stein E. Wade, Charles E. Thrasher, Terry N. Barnes, Paul R. Pyka, G. Nesvig, C. Greenleaf, John E.
Copyright Year	1996
Abstract	Oropharyngeal mechanisms activated by drinking have been shown to induce a rapid decline in plasma vasopressin which preceeds postabsorptive changes in plasma composition in the dehydrated dog. The present study was undertaken to determine what _actorls ) inhibit(s) vasopressin secretion after rehydration in water deprived human subjects. For this purpose, 8 volunteers (5 men and 3 women) underwent 24 hours of water deprivation during which they ate a standardized dry diet plus 4 g of tlaCl. A catheter was then inserted in an antecubital vein and the subjects remained seated during the time-course of the experiment. After 15 minutes, three dehydration control blood samples were taken 30, 9, and 3 minutes before rehydration began. At time O, the subjects drank lO ml/kg of water (17.5 0.5 °C) in 35 seconds to 4 minutes. Blood was then drawn 3, 6, 9, 12, 15, 30, and 60 minutes after drinking began. A control water replete sample was drawn before the start of the dehydration. Hematocrit (Hct) and hemoglobin (Hb) were determined on the day of the experiment, together with electrolytes and osmolalities which were measured on freshly separated serum. Plasma was immediately frozen and further analyzed by radioimmunoassay for renin activity (PRA), vasopressin (AVP), and aldosterone.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.gov/19980201070.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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