Development of chloride homeostasis in albino and pigmented rat visual cortex neurons.

Content Provider	Semantic Scholar
Author	Diykov, Dmitry G. Barmashenko, Gleb Hoffmann, Klaus-Peter
Copyright Year	2008
Abstract	Albinism has a profound effect on visual development and visual function. Pharmacologically significant alterations of the two most important chloride-transporters--KCC2 (outward transporter) and NKCC1 (inward transporter)--functions were found in albino visual cortex neurons, comprising a higher NKCC1 and a lower KCC2 action. In this study, we compare the early postnatal development of the reversal potential of gamma-aminobutyric acidAR-mediated currents in visual cortex neurons of albino and pigmented rats. At birth we found no differences. At the time of eye opening (second week postnatally) the reversal potential of gamma-aminobutyric acidAR-mediated currents is 15 mV more positive and intracellular Cl- concentration is higher in visual cortex neurons of albinos than of pigmented rats.
Starting Page	695
Ending Page	701
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://homepage.ruhr-uni-bochum.de/klaus-peter.hoffmann/pdf_hoffmann/diykov_neuroreport_08.pdf
PubMed reference number	18388745v1
Alternate Webpage(s)	https://doi.org/10.1097/WNR.0b013e3282f9e43c
DOI	10.1097/wnr.0b013e3282f9e43c
Journal	Neuroreport
Volume Number	19
Issue Number	5
Language	English
Access Restriction	Open
Subject Keyword	Cerebral cortex Chloride Ion Interferon Type II Membrane Transport Proteins Recombinant Interferon-gamma SLC12A2 wt Allele SLC12A5 gene Vision Visual Cortex
Content Type	Text
Resource Type	Article