NDLI: Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways

Content Provider	Semantic Scholar
Author	Escribano, Juan Pablo Gomez‐ Bibb, Mervyn
Copyright Year	2013
Abstract	Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products.
Starting Page	425
Ending Page	431
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/s10295-013-1348-5
PubMed reference number	24096958
Journal	Medline
Volume Number	41
Alternate Webpage(s)	https://www.nbi.ac.uk/systems/OpenAccess/46431
Alternate Webpage(s)	https://doi.org/10.1007/s10295-013-1348-5
Journal	Journal of Industrial Microbiology & Biotechnology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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