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Superoxide dismutase expression in the human corpus luteum during the menstrual cycle and in early pregnancy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sugino, Norihiro Takiguchi, Shuji Kashida, Shiro Karube, Akihiro Nakamura, Yasuhiko Kato, Hiroshi |
| Copyright Year | 2000 |
| Abstract | To investigate the possible role of the superoxide radical and its scavenging system in the human corpus luteum, superoxide dismutase (SOD) values and lipid peroxide concentrations were analysed in the corpora lutea during the menstrual cycle and in early pregnancy. Copper-zinc SOD (Cu,Zn-SOD) activities increased from the early to mid-luteal phase, and gradually decreased thereafter and were the lowest in the regression phase. In pregnant corpus luteum, Cu,Zn-SOD activities were significantly higher than those in the mid-luteal phase. In contrast, manganese SOD (Mn-SOD) activities were low in the mid-luteal phase and increased toward the regression phase. Changes in mRNA expression of both types of SOD were similar to changes in their activities. Lipid peroxide concentrations were the highest in the regression phase whereas they were remarkably low in pregnant corpus luteum. The effects of human chorionic gonadotrophin (HCG) on luteal SOD were studied in vitro. HCG significantly increased Cu,Zn-SOD expression in mid-luteal phase corpora lutea, but not in late luteal phase corpora lutea. In conclusion, the present study suggests that the superoxide radical and its scavenging system, especially Cu,Zn-SOD, play important roles in the regulation of human luteal function. The stimulation of luteal Cu, Zn-SOD expression by HCG may be important in maintaining luteal cell integrity when pregnancy occurs. |
| Starting Page | 19 |
| Ending Page | 25 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/molehr/6/1/10.1093_molehr_6.1.19/1/060019.pdf?Expires=1493007540&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=cOQvVtDCrnEPC3SRxKLprZ5AnRARVHafmRX3ZfBX4stq8WPTYjOTGWrKOXq5gjrve89UitE9iQwGfHIpGNG0f0QH8L6GaWCEf-DraNuCpZDm-VBIvkshpy2w2K0ALrd4UaDKPEVBSu~b-btIswLBrhyJU-yWDYQCY-faqpqrm-Df6bYYZWCRvERr6duFX~IA3Lf1EhhDTsVQ5uLjXgO0it3hvAHMwfOpZALHbz~sm8wT5q2xcrwuH6wwxL1NrJokC942C~6II5GsVJeX-bp5cc7mr4gAzNjAuUo-xHVyuKtFBZjxuf~x01opV-oOlC5Y24r9YYwz4LZG5MMAzu2BEA__ |
| PubMed reference number | 10611256v1 |
| Volume Number | 6 |
| Issue Number | 1 |
| Journal | Molecular human reproduction |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Body of uterus Gonadotropins Human Chorionic Gonadotropin Lipid Peroxides Luteal Cells Luteal Phase Manganese Poisoning Manganese Superoxide Dismutase Menstrual cycle Menstruation Receptors, LH Structure of corpus luteum of ovary Superoxides Zn-alpha-2-glycoprotein |
| Content Type | Text |
| Resource Type | Article |
