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The overexpression of homeotic complex gene Ultrabithorax in the post-embryonic neuronal lineages of the ventral nervous system in Drosophila melanogaster
| Content Provider | Semantic Scholar |
|---|---|
| Author | Katie E. |
| Copyright Year | 2010 |
| Abstract | Developing nervous systems face an immense challenge; neural precursor cells must differentiate into a variety of neuron types and then go on to establish functional synaptic connections at sometimes distant targets. Over a century of research has begun to elucidate the precise mechanisms responsible for this remarkable process. For most of that time, Drosophila melanogaster, the fruit fly, has proven to be an exceptional model organism for studying development processes. In addition to its short life cycle and ease of handling, Drosophila displays an array of genetic markers with which a number of sophisticated molecular tools have been generated. The genome of Drosophila can be manipulated with relative ease and the resulting phenotypes can be studied. Interestingly, hundreds of Drosophila genes have been conserved across species including humans, with their function providing insight to many normal biological and disease-related processes. In Drosophila, most nervous system studies thus far have focused on the embryo or on particular neuronal classes in the adult brain. The postembryonic neurons of the ventral nervous system, however, are proving to be interesting and useful subjects for studying neurological mechanisms. Arising from neural precursor cells called neuroblasts, these adult-specific neurons appear later in larval life. The progeny of each neuroblast forms a morphologically distinct neuronal lineage that sends out characteristic axon projections that arrest prior to metamorphosis and later sprout to form the neural connections of the adult. Analysis of these arrested neurons in late larval stages has |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://digitalcommons.bucknell.edu/cgi/viewcontent.cgi?article=1013&context=masters_theses |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
