NDLI: Facilitating influence of procainamide on conversion of atrial flutter by rapid atrial pacing.

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Facilitating influence of procainamide on conversion of atrial flutter by rapid atrial pacing.

Content Provider	Semantic Scholar
Author	Heisel, Armin Jung, J. K. Stopp, Matthias Schieffer, Hermann
Copyright Year	1997
Abstract	In a prospective, double-blind, randomized, placebocontrolled study we investigated the facilitating influence of intravenous procainamide on conversion of atrial flutter by rapid atrial pacing. Fifty consecutive patients with spontaneous sustained atrial flutter were 1:1 randomized into two homogenous groups: group A received 10 mg.kg-1 procainamide intravenously, group B placebo. After infusion there was a significant (P < 0.01) lengthening of the flutter cycle with respect to baseline in group A, exceeding the flutter cycle length of the control group (P < 0.05). The overall success rate of rapid atrial pacing in restoring sinus rhythm was significantly higher after pre-treatment with procainamide compared to placebo (100% vs 76%; P < 0.05): 20 patients of group A reverted immediately after pacing to sinus rhythm, the remaining five after a brief episode of atrial fibrillation. In the placebo group, 16 patients showed a prompt conversion to sinus rhythm and three after transient atrial fibrillation. In the remaining six patients, due to sustained pacing-induced atrial fibrillation, direct current cardioversion was necessary. After administration of procainamide a less aggressive stimulation protocol with significantly (P < 0.01) longer paced cycles to interrupt atrial flutter was achievable. In conclusion, intravenous procainamide augments the efficacy of atrial pacing to convert atrial flutter to sinus rhythm.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurheartj/18/5/10.1093/oxfordjournals.eurheartj.a015353/2/18-5-866.pdf?Expires=1493061893&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=N5j2MaKcOIH-rZVBTgUkKPs6Q4~-5idqOcId6duN6nwWddXtx55hsS1YV-EpmZBUJXD4ps8NQIp~iJbeQXYZeFX57URteyxJpW7EkLPYHnoSkSftotWxpJJ~Fyfx0-wTy8NZg0zTTDSeq-3C-rQF6HS~EX-DO0jv0z11JCYDkeEQfFlqJPd8mxhLMMgPMjYVhpMj0RL2b5xNR5yRuswW70aeg-Ydt0jr3bKkN27eHIDHaFDcc6NqkVO7LKYjjR4fCLqzoUFJ58gYaYqlJ-SuNYQVQEGVQlkOGzN30ZmvegcNRFOOKSTgOKzbIi4IDTcrKoNoTK18dn0txWqSq0K7NQ__
PubMed reference number	9152658v1
Volume Number	18
Issue Number	5
Journal	European heart journal
Language	English
Access Restriction	Open
Subject Keyword	Atrial Fibrillation Atrial Flutter Heart Atrium Nasal sinus Patients Procainamide
Content Type	Text
Resource Type	Article

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