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Adjunctive Treatment with Rhodiola Crenulata in Patients with Chronic Obstructive Pulmonary Disease – A Randomized Placebo Controlled Double Blind Clinical Trial
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chuang, Ming-Lung Wu, Tzu-Chin Wang, Yau-Tung Wang, Yau-Chen Tsao, Thomas C.-Y. Wei, James Cheng-Chung Chen, Chia-Yin Lin, I-Feng |
| Copyright Year | 2015 |
| Abstract | UNLABELLED Chronic obstructive pulmonary disease (COPD) is a low grade systemic inflammatory disease characterized by dyspnea and exercise intolerance even under standard therapy. Rhodiola crenulata (RC) has been shown to exert anti-inflammatory effects and to enhance exercise endurance, thereby having the potential to treat COPD. In this 12-week, randomized, double-blind, placebo-controlled clinical trial, 57 patients with stable moderate-to-severe COPD aged 70±8.8 years were given RC (250 mg twice/day) (n=38) or a placebo (250 mg twice/day) (n=19) in addition to their standard regimen. There were no significant differences in anthropometrics, quality of life, lung function, six-minute walk and incremental exercise tests between the two groups at enrollment. Over the 12 weeks, RC was well tolerated, significantly reduced triceps skin thickness (Δ=-1 mm, p=.04), change of FEV1 (4.5%, p=.03), and improved workload (Δ=10%, p=.01); although there were no significant differences in these factors between the two groups. However, there were significant between-group differences in tidal volume and ventilation-CO2-output ratio at peak exercise (both p=.05), which were significantly related to peak work rate (both p<.0001). RC tended to protect against acute exacerbation of COPD (p=.1) but not other measurements. RC did not improve the six-minute walk test distance but significantly improved tidal breathing and ventilation efficiency, most likely through improvements in work rate. Further studies with a larger patient population are needed in order to confirm these findings. TRIAL REGISTRATION ClinicalTrials.gov number NCT02242461. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 26098419 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | http://journals.plos.org/plosone/article/file?id=info:doi/10.1371/journal.pone.0128142.s003&type=supplementary |
| Alternate Webpage(s) | http://www.naturalhealthresearch.org/wp-content/uploads/2017/01/Rhodiola.pdf |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0128142 |
| Journal | PloS one |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
