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Water as a promoting media for 1,3-dipolar cycloaddition of phosphorylated azides to internal alkynes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Artyushin, Oleg I. Matveeva, Ekaterina V. Bushmarinov, Ivan S. Odinets, Irina L. |
| Copyright Year | 2012 |
| Abstract | The 1,3-cycloaddition of ω-phosphoryl azides to activated internal alkynes su ch as dimethyl acetylenedicarboxylate and tetramethyl acetylenedip hos honate as well sodium azide to tetramethyl acetylenediphosphonate readily proceeds in water without any co-solvent or additive to afford the corresponding phosphorylated 1,2,3-tr iazoles in excellent yields. The ester group in carbalkoxy function of these compounds can be easil y converted to carbamido group via the reaction with amines in MeOH thereby expanding the range of potentially biologically active heterocyclic aminophosphonates of such type. |
| File Format | PDF HTM / HTML |
| DOI | 10.3998/ark.5550190.0013.419 |
| Volume Number | 2012 |
| Alternate Webpage(s) | https://quod.lib.umich.edu/cgi/p/pod/dod-idx/water-as-a-promoting-media-for-13-dipolar-cycloaddition.pdf?c=ark&format=pdf&idno=5550190.0013.419 |
| Alternate Webpage(s) | https://doi.org/10.3998/ark.5550190.0013.419 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
