NDLI: Urinary excretion of homovanillic acid in workers exposed to manganese

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Urinary excretion of homovanillic acid in workers exposed to manganese

Content Provider	Semantic Scholar
Author	Buchet, J. P. Magos, Clementina Roels, Harry A. Ceulemans, Eva Lauwerys, Robert R.
Copyright Year	1993
Abstract	SummaryHomovanillic acid, an end product of dopamine catabolism, and manganese (Mn) were measured in the urine of 68 male workers exposed to Mn-containing dust in a dry alkaline battery plant or an Mn oxide and salt producing plant, and in 35 control male subjects. The geometric mean of the airborne concentration of inhalable (total) dust amounted to 0.95 and 1.37 mg/m3 in the dry alkaline battery plant and the Mn oxide and salt producing plant, respectively. In the latter, a higher prevalence of increased values of urinary homovanillic acid concentration was found. In the total population, there was a low but statistically significant positive correlation between the concentration of homovanillic acid and Mn in urine (r = 0.20, P = 0.04) but there was no significant correlation between the level of homovanillic acid in urine and Mn in airborne dust or duration of exposure. This observation might be compatible with the stimulation of dopamine turnover in the brain, which has been observed in the early phase of Mn intoxication in animals. However, the large variability in urinary homovanillic acid excretion in control subjects precludes the use of this biological indicator to detect early interference of Mn with the dopaminergic system.
Starting Page	131
Ending Page	133
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1007/BF00405732
PubMed reference number	8253511
Journal	Medline
Volume Number	65
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1007/BF00405732
Alternate Webpage(s)	https://doi.org/10.1007/BF00405732
Journal	International archives of occupational and environmental health
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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